Article Navigation
- < Previous
- Next >
Journal Article
Get access
, Toby J. Athersuch Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK toby.athersuch@imperial.ac.uk Search for other works by this author on: Oxford Academic Daniel J. Antoine MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, EH16 4TJ, UK Search for other works by this author on: Oxford Academic Alan R. Boobis Department of Medicine, Imperial College London, London W12 0NN, UK Search for other works by this author on: Oxford Academic Muireann Coen Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK Search for other works by this author on: Oxford Academic Ann K. Daly Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK Search for other works by this author on: Oxford Academic Lucia Possamai Department of Hepatology, St Mary's Hospital, Imperial College London, London W2 1NY, UK Search for other works by this author on: Oxford Academic Jeremy K. Nicholson Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK Search for other works by this author on: Oxford Academic Ian D. Wilson Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK Search for other works by this author on: Oxford Academic
Toxicology Research, Volume 7, Issue 3, May 2018, Pages 347–357, https://doi.org/10.1039/c7tx00340d
Published:
06 March 2018
Article history
Received:
21 December 2017
Accepted:
07 February 2018
Published:
06 March 2018
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Toby J. Athersuch, Daniel J. Antoine, Alan R. Boobis, Muireann Coen, Ann K. Daly, Lucia Possamai, Jeremy K. Nicholson, Ian D. Wilson, Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective, Toxicology Research, Volume 7, Issue 3, May 2018, Pages 347–357, https://doi.org/10.1039/c7tx00340d
Close
Search
Close
Search
Advanced Search
Search Menu
Abstract
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity. The pharmacological properties of APAP are the focus of some activity, with the role of the metabolite N-arachidonoylaminophenol (AM404) still a topic of debate. However, that the hepatotoxicity of APAP results from the production of the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI/NABQI) that can deplete glutathione, react with cellular macromolecules, and initiate cell death, is now beyond dispute. The disruption of cellular pathways that results from the production of NAPQI provides a source of potential biomarkers of the severity of the damage. Research in this area has provided new diagnostic markers such as the microRNA miR-122 as well as mechanistic biomarkers associated with apoptosis, mitochondrial dysfunction, inflammation and tissue regeneration. Additionally, biomarkers of, and systems biology models for, glutathione depletion have been developed. Furthermore, there have been significant advances in determining the role of both the innate immune system and genetic factors that might predispose individuals to APAP-mediated toxicity. This perspective highlights some of the progress in current APAP-related research.
Graphical Abstract
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.
Open in new tabDownload slide
Issue Section:
Review
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective - 24 Hours access
EUR €51.00
GBP £44.00
USD $55.00
Advertisement
Citations
Views
7,714
Altmetric
More metrics information
Metrics
Total Views 7,714
5,912 Pageviews
1,802 PDF Downloads
Since 1/1/2020
Month: | Total Views: |
---|---|
January 2020 | 20 |
February 2020 | 27 |
March 2020 | 38 |
April 2020 | 30 |
May 2020 | 15 |
June 2020 | 18 |
July 2020 | 28 |
August 2020 | 43 |
September 2020 | 77 |
October 2020 | 63 |
November 2020 | 49 |
December 2020 | 99 |
January 2021 | 113 |
February 2021 | 100 |
March 2021 | 153 |
April 2021 | 132 |
May 2021 | 171 |
June 2021 | 125 |
July 2021 | 92 |
August 2021 | 111 |
September 2021 | 132 |
October 2021 | 199 |
November 2021 | 123 |
December 2021 | 101 |
January 2022 | 117 |
February 2022 | 110 |
March 2022 | 219 |
April 2022 | 158 |
May 2022 | 160 |
June 2022 | 138 |
July 2022 | 65 |
August 2022 | 133 |
September 2022 | 171 |
October 2022 | 230 |
November 2022 | 138 |
December 2022 | 152 |
January 2023 | 203 |
February 2023 | 197 |
March 2023 | 233 |
April 2023 | 217 |
May 2023 | 177 |
June 2023 | 154 |
July 2023 | 131 |
August 2023 | 121 |
September 2023 | 130 |
October 2023 | 156 |
November 2023 | 224 |
December 2023 | 168 |
January 2024 | 154 |
February 2024 | 168 |
March 2024 | 247 |
April 2024 | 213 |
May 2024 | 260 |
June 2024 | 201 |
July 2024 | 98 |
August 2024 | 145 |
September 2024 | 182 |
October 2024 | 45 |
November 2024 | 40 |
Altmetrics
Email alerts
Article activity alert
Advance article alerts
New issue alert
In progress issue alert
Receive exclusive offers and updates from Oxford Academic
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
More from Oxford Academic
Biochemistry
Biological Sciences
Clinical Medicine
Medical Toxicology
Medicine and Health
Science and Mathematics
Toxicology (Non-medical)
Books
Journals
Advertisement